What is Grignard reagent?

An organomagnesium compound with the general formula RMgX is known as a Grignard Reagent. Where R represents organic groups such as alkyl or aryl, X represents Halogen gases, and Mg is the symbol of Magnesium.

Explain the preparation of Grignard Reagent in the laboratory.

Reaction of organic halide with magnesium in anhydrous ether leads to the formation of Grignard reagent. It is essential for the reaction to conduct in anhydrous condition because Grignard reagents react vigorously with water.

Why Grignard reagent is prepared in anhydrous conditions?

The Grignard reagent is prepared under anhydrous conditions is because of the reaction of the Grignard reagent with water. It reacts very quickly with any proton-containing compound and forms a hydrocarbon. So the effect of the Grignard reagent and its application is lost. The removal of moisture before conducting the preparation is very necessary. R-Mg-X+H 2 O→R-H+Mg(OH)X

What are the precautions considered while handling Grignard reagent?

The Grignard reagent is highly reactive. There are certain precautions to consider while handling Grignard reagent: Must be kept away from water. Gloves and Goggles should be used while handling Reactions of the Grignard reagent must be carried out in a ventilated place Proper disposal

Can Grignard reagents react with Solvents?

Yes, Grignard reagent reacts with many solvents, particularly those containing acidic protons such as alcohol, water, and acids.

What are the common applications of Grignard Reagent?

Grignard reagents are widely used in organic chemistry : In the formation of alcohols by nucleophilic addition to carbonyl compounds (aldehydes and ketones). In the synthesis of various complex organic molecules. The preparation of carboxylic acids and other functional groups via reactions with carbon dioxide.

What happens when a Grignard reagent reacts with water?

When a Grignard reagent reacts with water, it forms an alkane and magnesium hydroxide. For example: R-Mg-X + H2O→ R-H + Mg(OH)X

How do Grignard reagents react with nitriles?

Grignard reagents add to the carbon of nitriles (R-C&equiv;N), forming an imine intermediate. Upon hydrolysis, this yields a ketone. If excess Grignard reagent is used, it can further react with the ketone to form a tertiary alcohol.

How do Grignard reagents interact with carbon dioxide?

Grignard reagents react with carbon dioxide to form carboxylic acids (after acidic workup). The nucleophilic carbon of the Grignard reagent attacks the electrophilic carbon of CO2, forming a magnesium salt of a carboxylic acid, which is then converted to the free acid upon acidification.

How do Grignard reagents react with epoxides?

Grignard reagents open epoxide rings in a nucleophilic addition reaction. The nucleophilic carbon attacks the less substituted carbon of the epoxide, resulting in ring opening. After workup, this produces an alcohol with the hydroxyl group on the more substituted carbon.

Can Grignard reagents be used to synthesize aldehydes directly?

Grignard reagents cannot directly synthesize aldehydes from simple carbonyl compounds, as they tend to over-add. However, aldehydes can be indirectly synthesized using Grignard reagents by reacting them with compounds like ethyl formate or N-formylpiperidine, followed by hydrolysis.

What is the Barbier reaction and how does it relate to Grignard reagents?

The Barbier reaction is a one-pot version of the Grignard reaction where the organohalide, magnesium, and carbonyl compound are mixed together. It produces similar products to the Grignard reaction but can be advantageous when the Grignard reagent is unstable or difficult to prepare separately.

What is the synthetic utility of reacting Grignard reagents with acid chlorides?

Reacting Grignard reagents with acid chlorides typically results in the formation of ketones. However, careful control is needed as the ketone product can further react with excess Grignard reagent to form a tertiary alcohol. This reaction is useful for synthesizing unsymmetrical ketones.

How does the structure of a Grignard reagent contribute to its reactivity?

The structure of a Grignard reagent (RMgX) features a highly polarized carbon-magnesium bond, with the carbon bearing a partial negative charge. This makes the carbon a strong nucleophile, able to attack electrophilic centers in other molecules, leading to its high reactivity.

How does the nature of the R group affect the reactivity of Grignard reagents?

The nature of the R group influences reactivity. Generally, alkyl Grignard reagents are more reactive than aryl Grignard reagents. Within alkyl groups, primary > secondary > tertiary in terms of reactivity, due to steric factors affecting the approach to electrophiles.

Why are Grignard reagents considered "umpolung" reagents?

Grignard reagents are considered "umpolung" (polarity inversion) reagents because they convert the normally electrophilic carbon of an alkyl halide into a nucleophilic carbon. This reversal of polarity allows for unique synthetic transformations not easily achieved by other means.

What is the difference between Grignard reagents and organolithium compounds?

While both are organometallic reagents, Grignard reagents (RMgX) are generally less reactive than organolithium compounds (RLi). Grignard reagents are more stable, easier to handle, and often more selective in their reactions, making them preferred in many synthetic applications.

Why must Grignard reagents be prepared in anhydrous conditions?

Grignard reagents are extremely sensitive to moisture. Water reacts rapidly with the reagent, destroying it and forming the corresponding alkane. Anhydrous conditions are essential to prevent this unwanted reaction and maintain the reagent's effectiveness.

What is the role of ether in Grignard reagent preparation?

Ether serves as both a solvent and a stabilizing agent in Grignard reagent preparation. It solvates the magnesium atom, helping to stabilize the reagent and prevent it from decomposing. The oxygen in ether also coordinates with magnesium, further enhancing stability.

Can all halides be used to form Grignard reagents?

Not all halides are equally effective in forming Grignard reagents. The order of reactivity is typically I > Br > Cl >> F. Fluorides are rarely used due to their low reactivity. Iodides and bromides are most commonly employed in Grignard reagent preparation.

How does the presence of other functional groups affect Grignard reagent formation?

Functional groups that are acidic or can act as electrophiles (e.g., -OH, -COOH, -NH2, -C=O) interfere with Grignard reagent formation. These groups must be protected or absent, as they would react with the Grignard reagent once formed, destroying it.

What precautions must be taken when working with Grignard reagents?

Grignard reagents are highly reactive and moisture-sensitive. Precautions include using anhydrous solvents and glassware, working under an inert atmosphere (like nitrogen or argon), and avoiding exposure to air or moisture. They're also often pyrophoric, requiring careful handling to prevent fires.

How do Grignard reagents react with aldehydes and ketones?

Grignard reagents act as nucleophiles, attacking the electrophilic carbonyl carbon of aldehydes and ketones. This results in the formation of alkoxides, which upon workup with acid, yield secondary and tertiary alcohols respectively. This reaction is a key method for alcohol synthesis.

What is a Grignard reagent and why is it important in organic chemistry?

A Grignard reagent is an organometallic compound formed by the reaction of an alkyl or aryl halide with magnesium metal in anhydrous ether. It's important in organic chemistry because it's a powerful nucleophile used to form carbon-carbon bonds, allowing for the synthesis of complex organic molecules.

What is the Schlenk equilibrium and why is it important in understanding Grignard reagents?

The Schlenk equilibrium describes the interconversion between RMgX and R2Mg + MgX2 in solution. It's important because it shows that the actual reactive species in Grignard reactions can be more complex than the simple RMgX formula suggests, affecting reactivity and selectivity.

What is the significance of the Grignard reaction in carbon-carbon bond formation?

The Grignard reaction is a powerful method for forming new carbon-carbon bonds, allowing the extension of carbon chains and the synthesis of complex organic molecules. This makes it invaluable in organic synthesis, from small-scale laboratory work to industrial processes.

How do Grignard reagents behave as bases?

Grignard reagents are strong bases due to the highly polarized C-Mg bond. They can deprotonate weak acids like alcohols, terminal alkynes, and even water. This basicity can sometimes compete with their nucleophilic character in reactions.

How can you determine if a Grignard reagent has formed successfully?

Successful Grignard reagent formation is often indicated by the disappearance of the magnesium metal and the solution turning cloudy or dark. A more definitive test is to react a small sample with a carbonyl compound and check for the formation of the expected alcohol product.

What is the role of iodine in initiating Grignard reagent formation?

Iodine acts as an activator in Grignard reagent formation. It reacts with the magnesium surface to remove the oxide layer, exposing fresh metal. This clean metal surface can then react more readily with the alkyl or aryl halide to form the Grignard reagent.

How do Grignard reagents behave differently from other organometallic compounds?

Grignard reagents are less reactive than organolithium compounds but more reactive than most organocuprates. They strike a balance between reactivity and selectivity, making them versatile in organic synthesis. Unlike many organometallics, they're relatively stable at room temperature if kept dry.

Can Grignard reagents be used in cross-coupling reactions?

Yes, Grignard reagents can be used in cross-coupling reactions, particularly in Kumada coupling. Here, a Grignard reagent is coupled with an aryl or vinyl halide using a nickel or palladium catalyst, forming a new carbon-carbon bond. This is valuable for synthesizing biaryl compounds.

How do Grignard reagents interact with esters?

Grignard reagents react with esters to form tertiary alcohols. The reaction proceeds through a ketone intermediate, but this usually reacts immediately with a second equivalent of the Grignard reagent. This reaction is useful for synthesizing tertiary alcohols with two identical R groups.

What is the importance of the Grignard reagent in industrial chemistry?

In industry, Grignard reagents are used to synthesize various pharmaceuticals, agrochemicals, and fine chemicals. They're valuable for producing alcohols, ketones, and other functionalized organic compounds on a large scale. Their versatility and relatively low cost make them industrially important.

How does the presence of β-hydrogen atoms affect Grignard reagent stability?

Grignard reagents with β-hydrogen atoms can undergo β-elimination, forming an alkene and reducing the yield of the desired product. This is more problematic for secondary and tertiary Grignard reagents. To minimize this, reactions are often conducted at lower temperatures.

What is the role of Grignard reagents in the synthesis of organophosphorus compounds?

Grignard reagents can react with phosphorus halides to form organophosphorus compounds. For example, reacting a Grignard reagent with PCl3 can produce phosphines (PR3). This is an important method for synthesizing ligands used in organometallic chemistry and catalysis.

How do Grignard reagents react with oxygen?

Grignard reagents react rapidly with oxygen, forming peroxides initially. These peroxides can decompose explosively, making the reaction dangerous. The final products are typically alcohols or phenols, depending on whether the Grignard reagent is alkyl or aryl.

What is the Bouveault aldehyde synthesis, and how does it utilize Grignard reagents?

The Bouveault aldehyde synthesis uses Grignard reagents to produce aldehydes. It involves reacting a Grignard reagent with ethyl formate, followed by acidic workup. This method is particularly useful for synthesizing aldehydes that are one carbon longer than the starting Grignard reagent.

How can Grignard reagents be used to synthesize symmetrical ketones?

Symmetrical ketones can be synthesized by reacting Grignard reagents with diethyl carbonate. Two equivalents of the Grignard reagent react with the carbonate, forming a ketone with two identical R groups after acidic workup. This method is useful when direct oxidation of secondary alcohols is challenging.

What is the Grignard exchange reaction?

The Grignard exchange reaction involves the exchange of organic groups between a Grignard reagent and an organohalide. For example, PhMgBr can react with EtI to form EtMgBr and PhI. This is useful for preparing Grignard reagents that are difficult to form directly from the halide and magnesium.

What is the significance of the Grignard reagent in total synthesis?

In total synthesis of complex natural products, Grignard reagents are valuable tools for carbon-carbon bond formation and functional group interconversion. They allow for the controlled addition of carbon fragments and can be used to introduce specific stereochemistry, making them crucial in building complex molecular architectures.

How do Grignard reagents react with α,β-unsaturated carbonyl compounds?

Grignard reagents typically undergo 1,2-addition with α,β-unsaturated carbonyl compounds, adding to the carbonyl carbon rather than the β-carbon. This is in contrast to many other nucleophiles that prefer 1,4-addition. The 1,2-selectivity can be useful in synthesizing allylic alcohols.

Grignard Reagent - Structure, Preparation, Application, Uses, FAQs

Team Careers360Updated on 13 Aug 2025, 12:23 PM IST

Have you ever wondered how a whole molecule is formed just by starting with something as simple as an alkyl halide? The answer to this question will be known after reading this article on the Grignard reagent. Grignard reagent is an Organometallic compound written as RMgX, where R is an alkyl or aryl group and X is a halogen. Just as salt is inseparable from food, so is the Grignard reagent from Organic chemistry.

This Story also Contains

Structure Of Grignard Reagent
Preparation Of Grignard Reagent
Applications Of Grignard Reagents
Uses Of Grignard Reagent
Some Solved Examples

Grignard Reagent

A French Chemist named Francois Grignard discovered this reagent in 1900. He was investigating the organic reactions of halides with metals, and while reacting different metals with organic halides, he noticed that the reaction of magnesium with organic halides in the presence of dry ether forms a very reactive organo-magnesium compound. Due to this discovery, he was awarded the Nobel Prize in 1912. In this article, we will cover the topic of the Grignard Reagent. This topic falls under the broader category of Haloalkanes And Haloarenes, which is a crucial chapter in (Class 12 Chemistry). It is not only essential for board exams but also for competitive exams like the JEE Mains Exam , National Eligibility Entrance Test (NEET), and other entrance exams such as SRMJEE, BITSAT, WBJEE, BCECE, and more

Structure Of Grignard Reagent

The structure of Grignard’s reagent involves a polar carbon-magnesium bond, with magnesium having a partially positive charge and carbon having a partially negative charge. The polarisation enables Grignard’s reagent to act as a strong nucleophile that can attack an electrophilic centre. Grignard’s reagent exists as a monomer and dimer and is stabilized by an ether molecule coordinated with the magnesium atom.

Structure of Grignard reagent

Preparation Of Grignard Reagent

Grignard reagents are prepared from magnesium metal by treating it with an organic halide. For stabilizing these organomagnesium compounds ethers are required. These compounds require air-free conditions, and the use of protic solvents may not be used as it will create protonolysis or oxidation may destroy these compounds.

However, this compound can be formed in solution by the use of ultrasound since it activates the magnesium and, thereby, consumes water present in the solution. An anhydrous condition is more suitable for the preparation of the Grignard reagent. Following the correct procedures results in the formation of the Grignard reagent. The following figure shows the preparation of the Grignard reagent from an organic halide.

Preparation of Grignard reagent

Applications Of Grignard Reagents

Synthetic Application

1. Formation of Alkane

Grignard reagent, on reaction with any compound containing an active H atom, produces an alkane.

$\mathrm{MgRX}+\mathrm{HZ} \rightarrow \mathrm{MgXZ}+\mathrm{RH}$

2. Formation Of Alkene

Unsaturated halide with Grignard reagent gives alkene

$\mathrm{CH}_3 \mathrm{MgI}+\mathrm{CH}_2=\mathrm{CHI} \longrightarrow \mathrm{CH}_2=\mathrm{CHCH}_3+\mathrm{MgI}_2$

3. Formation of Alkynes

Lower alkyne $+G R \rightarrow$ Product $\xrightarrow[\text { haldide }]{\text { alks }}$ Higher alkyne

$\mathrm{R}-\mathrm{C} \equiv \mathrm{C}-\mathrm{H}+\mathrm{CH}_3 \mathrm{MgBr} \xrightarrow[-\mathrm{CH}_4]{ } \mathrm{R}-\mathrm{C} \equiv \mathrm{C}-\mathrm{MgBr}$

4. Formation of Alcohol

(a) Primary alcohol: Obtained from :
(i) Dry oxygen
(ii) Epoxy ethane
(iii) Formaldehyde

(b)Secondary Alcohol: obtained from:

(i) all aldehydes except formaldehyde

(ii) Ethyl formate + 2 moles of RMgX

(c) Tertiary Alcohol: Obtained from:

(i) All esters except ethyl formate

(ii) All ketones

(iii) (RCOCl) + 2 moles of RMgX

5. Formation of Aldehydes:

(i) From HCN

(ii) From ethyl formate + 1 mole of RMgX

6. Formation of ketones:

(i) Alkyl Cyanide

$\mathrm{CH}_3 \mathrm{CN}+\mathrm{C}_2 \mathrm{H}_5 \mathrm{MgBr} \rightarrow \mathrm{CH}_3 \mathrm{COC}_2 \mathrm{H}_5+\mathrm{NH}_3+\mathrm{MgBrOH}$

(ii) Acetyl Chloride

$\mathrm{CH}_3 \mathrm{COCl}+\mathrm{CH}_3 \mathrm{MgX} \rightarrow \mathrm{CH}_3 \mathrm{COCH}_3+\mathrm{MgXCl}$

Reaction With Carbonyl Compounds

Grignard reagents react with carbonyl compounds like ketones and aldehydes to form corresponding alcohols. The nature of the substituent that gets attached to the carbonyl compound determines the product. When methanal is used as an aldehyde, the obtained alcohol will be primary, and if any aldehyde other than this is used, a secondary aldehyde is obtained. It can also be used for the alkylation of aldehydes and ketones. The Grignard reagent acts as a nucleophile, and thereby nucleophilic substitution reactions take place. The figure below shows the reaction of the Grignard reagent to form Benzyl alcohol.

Reaction Of The Grignard Reagent With Water

The reaction of a carbonyl compound with the Grignard reagent.

Grignard Reagents Acting as a Base

Grignard reagents are basic compounds and they react with phenol alcohol acceptor to give their corresponding alkoxides that is ROMgBr.

Related Topics Link,

NEET Highest Scoring Chapters & Topics

This ebook serves as a valuable study guide for NEET exams, specifically designed to assist students in light of recent changes and the removal of certain topics from the NEET exam.

Download EBook

Grignard agents can be used for the alkylation of metals

Grignard reagents react with the metal to form their related compound. For example, when the Grignard reagent reacts with cadmium chloride, it forms a dialkyl cadmium by the transmethylation reaction. The following reaction explains this.

$2 \mathrm{RMgX}+\mathrm{CdCl}_2 \mathrm{R}_2 \mathrm{Cd}\rightarrow 2 \mathrm{MgXCl}$

Schlenk Equilibrium

Grignard reagent reaction with dioxane to give diorganomagnesium compounds, and the reaction involving is known as the Schlenk equilibrium. And the reaction is conducted in a solvent that is diethyl ether and tetrahydrofuran.

$2 \mathrm{RMgX}+$ dioxane $\rightarrow \mathrm{R}_2 \mathrm{Mg}+\mathrm{MgX} \mathrm{X}_2$

Oxidation

Grignard reagent reacts with oxygen and forms magnesium organic peroxide. The further hydrolysis of the compound obtained hydroperoxides or alcohol. The following reaction shows the formation of this, and it proceeds in radical intermediates.

Also Read:

Uses Of Grignard Reagent

Grignard reagents are a very important organic compound that has many applications in the chemical field, mainly the organic chemistry field.
Grignard reagents have industrial applications, also. The very important use of the Grignard reagent is the production of tamoxifen a medicine used for the treatment of breast cancer. The reaction below shows the preparation of tamoxifen.

preparation of tamoxifen

Grignard reagents can be used to produce alcohol from epoxides.
Grignard reagent reaction with aldehyde, ketone, and esters to form alcoholic compounds.
It can be used for the degradation reaction of Grignard reagents used for the chemical analysis of triacylglycerol, and also for some cross-coupling reactions that are involved in the formation of carbon-carbon and carbon-hydrogen bonds.
It can be used for the synthesis of many organometallic compounds.
Grignard reagents are best for the preparation of amides, acetals, amino compounds, organosulfur compounds, ethers, ketones, aldehydes, etc.
It can be used for the production of several compounds that have a very important application in the pharmaceutical, perfume, and specialty chemicals fields.
Grignard reagents are used for the production of optically active compounds by the reaction of a secondary alcohol with the alkyl halides in the presence of a chiral phosphine metal as a catalyst.

Also check-

NCERT Exemplar Class 11th Chemistry Solutions	NCERT Solutions for Class 11 Chemistry
NCERT Exemplar Class 12th Chemistry Solutions	NCERT Solutions for Class 12 Chemistry
NCERT Exemplar Solutions for All Subjects	NCERT Solutions for All Subject

Some Solved Examples

Question.1 When phenyl magnesium bromide reacts with tert. Butanol, which of the following is formed?

1)Tert. butyl methyl ether

2) (correct)Benzene

3)Tert. butyl benzene

4)Phenol

Solution

As we learned,

Zerewitinoff Method -

The reaction of the alcohol with the Grignard reagent.

- wherein

$R^{\prime} OH+RMgX \rightarrow RH+R^{\prime} OMgX$

C₆H₅MgBr + (CH₃)₃C-OH $\rightarrow$ C₆H₆ + [(CH₃)₃Co]MgBr

Hence, the answer is option (2).

Question 2 Reaction of ROH with R'MgX produces:

1)RH

2) (correct)R'H

3)R-R

4)R-R'

Solution

Alkyl magnesium halides(RMgX) are called Grignard reagents. These undergo double decomposition reactions with water, ammonia, alcohol or amine having active H atom(attached to strongly electronegative O, N, S, or F and triple bond, etc.) to give alkane corresponding to an alkyl group of Grignard reagent. The reaction occurs as follows:

Reaction of Grignard reagent

So,

R'MgX+ROH$\rightarrow$R'H+Mg(OR)X

Therefore, option (2) is correct.

Question.3 Which of the following compounds will form a hydrocarbon on reaction with a Grignard reagent?

1) (correct)CH₃CH₂OH
2)CH₃CHO

3)CH₃COCH₃

4)CH₃CO₂CH₃

Solution

Reaction of Grignard reagent with H2O -

Alkane / Benzene is obtained

- wherein

Phenyl magnesium Bromide

Reaction of Grignard reagent with Alcohol -

Alkane is obtained.

- wherein

Grignard reagent

Practice More Questions From The Link Given Below

For more questions to practice, the following MCQs will help in the preparation for competitive examinations

Grignard Reagent - 1 Practice MCQS

Grignard Reagent - 2 Practice MCQs

Some related topics:

Preparation Of Alkanes	Preparation Of Alcohols
Physical & Chemical Properties Of Haloalkanes	Reaction Of Aldehydes And Ketones

Frequently Asked Questions (FAQs)

Q: How do Grignard reagents interact with boronic esters?

Grignard reagents can react with boronic esters in a transmetalation process. This reaction exchanges the organic group from magnesium to boron, forming a new organoboron compound. This is useful in organic synthesis, particularly in preparing reagents for Suzuki coupling reactions.

Q: What is the role of Grignard reagents in the synthesis of organometallic compounds of other metals?

Grignard reagents can be used to prepare organometallic compounds of other metals through transmetalation reactions. For example, they can react with salts of copper, zinc, or mercury to form the corresponding organometallic compounds. This is useful for preparing reagents with different reactivities and selectivities.

Q: How can Grignard reagents be used to introduce deuterium into organic molecules?

Grignard reagents can be used to introduce deuterium by using D2O in the quenching step instead of H2O. The magnesium-carbon bond is cleaved by D2O, introducing a deuterium atom. This method is useful for isotopic labeling in mechanistic studies or for preparing deuterated compounds for spectroscopic analysis.

Q: What is the Grignard version of the Reformatsky reaction?

The Grignard version of the Reformatsky reaction involves the reaction of a Grignard reagent with α-halo esters or ketones. This forms β-hydroxy esters or ketones, similar to the traditional Reformatsky reaction but often with better yields and under milder conditions.

Q: How do Grignard reagents participate in carbometalation reactions?

In carbometalation, Grignard reagents can add across carbon-carbon multiple bonds (like alkynes or alkenes) in the presence of suitable catalysts. This results in the formation of a new carbon-carbon bond and a carbon-magnesium bond, which can be further functionalized. It's useful for synthesizing complex organic molecules.

Q: What is the Grignard reduction and when is it useful?

The Grignard reduction refers to the reduction of ketones or aldehydes to alcohols using Grignard reagents derived from alkyl halides with β-hydrogens. The β-hydrogen is transferred to the carbonyl, resulting in reduction instead of addition. This is useful when a simple reduction is needed without introducing new carbon atoms.

Q: How do Grignard reagents interact with sulfur compounds?

Grignard reagents can react with various sulfur compounds. For example, they can add to sulfoxides to form sulfides, or react with disulfides to form thioethers. These reactions are useful in the synthesis of organosulfur compounds, which have applications in organic and medicinal chemistry.

Q: What is the role of Grignard reagents in the Wurtz-Fittig reaction?

While Grignard reagents aren't directly used in the Wurtz-Fittig reaction, they share similarities in mechanism. Both involve organomagnesium intermediates. Understanding Grignard chemistry helps in comprehending the Wurtz-Fittig reaction, which couples aryl halides with alkyl halides using sodium.

Q: How can Grignard reagents be used in the synthesis of tertiary amines?

Grignard reagents can react with imines or their derivatives (like iminium ions) to form tertiary amines after workup. This reaction is analogous to their addition to carbonyls but results in C-N bond formation instead of C-O. It's a useful method for introducing alkyl or aryl groups onto nitrogen.

Q: What is the Fourneau-Tiffeneau rearrangement and how does it involve Grignard reagents?

The Fourneau-Tiffeneau rearrangement is a reaction where α-haloketones are treated with Grignard reagents to form aldehydes or ketones with one fewer carbon. The Grignard reagent initiates a rearrangement, resulting in the loss of a carbon atom from the original ketone.

Articles

BiPC Courses After 12th - Fees, Eligibility, Duration & Top Institutes

Aug 25, 2025

UPTAC Cutoff 2025 Round 3 (Out) - AKTU Opening and Closing Rank

Aug 23, 2025

UPTAC Counselling 2025 (Started): Internal Sliding, Seat Allotment, Choice Filling, Document Verification

Aug 23, 2025

UPTAC Seat Allotment 2025 for Internal Sliding (Out) - Link, Fee, Seat Acceptance, Reporting

Aug 23, 2025