Why does CML cancer develop?
Answer (1)
24th Feb, 2023
The BCR-ABL1 fusion gene is responsible for all occurrences of CML. This gene is absent from healthy blood cells. In a single bone marrow cell during cell division, a translocation between regions of chromosomes 9 and 22 results in the formation of the BCR-ABL1 gene. The Philadelphia chromosome is the aberrant chromosome 22. (Ph chromosome).
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