- Introduction
Online
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Quick facts
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Medium of instructions
English
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Mode of learning
Self study
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Mode of Delivery
Video and Text Based
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Course and certificate fees
Fees information
certificate availability
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The syllabus
Introduction
Structure of Antibodies/Immunoglobulin
- Basic Structure of immunoglobulin or antibodies
- Functional components of Antibodies
- Summary- Basic structure of antibodies
- Antibody sequencing to know different types of light and heavy chains of Abs
- Types of light chains
- Types of heavy chains
- Quiz on structure of antibodies
Detailed Structure of Antibodies/Immunoglobulin
- Immunoglobulin Domains
- Complementarity determining regions (CDRs)
- Framework region
- Binding of antigen to CDRs
- Role of Hinge Region
- Summary- Detailed structure of antibodies
- Quiz
Antibody classes and their biological activities
- Immunoglobulin G or IgG
- Immunoglobulin A or IgA
- Immunoglobulin M or IgM
- Immunoglobulin E or IgE
- Immunoglobulin D or IgD
- Summary- Antibody classes and their biological activities
- Quiz on functions of antibodies
Complement System
- Introduction to complement system
- Nomenclature of complement proteins
- Classical pathway of complement activation
- Alternative pathway of complement activation
- Lectin Pathway of complement activation
- Membrane Attack Complex (MAC)
- Summary- Complement system
- Quiz on complement system
- Regulation of the complement system
- Other functions of complement proteins
- Quiz on regulation of the complement system
Organization of immunoglobulin genes
- Germline & somatic hypermutation Theory
- Tonegawa’s Theory- Immunoglobulin genes rearrange
- Organization of Ig genes
- Organization of gene segments encoding light chains
- Organization of gene segments encoding heavy chains
- Quiz on organization of immunoglobulin genes
V(D)J Recombination
- VJ recombination in kappa light chain DNA
- VJ recombination in ƛ light chain DNA
- VDJ recombination in heavy chain DNA
- Quiz on V(D)J recombination
- Mechanism of variable region DNA rearrangements
- Quiz
Generation of antibody diversity
- Combinatorial VJ and VDJ joining
- Junctional Flexibility
- P-addition
- N-addition
- Somatic Hypermutation
- Quiz on generation of antibody diversity
Expression of immunoglobulin genes
- Class switching
- Mechanism of class switching
- Factors that govern class switching
- Quiz on class switching
Membrane bound and secreted Antibodies/Immunoglobulin
- Membrane bound immunoglobulins and BCRs
- Expression of membrane bound or secreted Immunoglobulin
- Simultaneous expression of IgM and IgD on mature B cells
- Quiz on mIg and sIg
Regulation of Immunoglobulin gene transcription
- Regulatory sequences in DNA
- Allelic exclusion
- Mechanism of allelic exclusion
- Quiz on Ig gene regulation
Antigenic determinants/Epitopes on Immunoglobulin
- Isotypic determinants
- Role of anti-isotype antibodies in detection of viral diseases
- Allotypic determinants
- Idiotypic determinants
- Types of anti-ID antibodies
- Specific uses of anti-ID antibodies
- Quiz on antigenic determinants on immunoglobulins
Polyclonal and Monoclonal Antibodies
- Polyclonal Antibodies
- Monoclonal Antibodies
- Hybridoma Technology (Production of Monoclonal Antibodies)
- Selection of Hybridoma cells producing Monoclonal Antibodies
- Quiz on Polyclonal and Monoclonal Antibodies
Antibody Engineering
- Advantages of therapeutic monoclonal antibodies over conventional drugs
- Chimeric Monoclonal Antibodies
- Humanized Monoclonal Antibodies
- Fully Human Monoclonal Antibodies
- Isolation of monoclonal antibodies directly from humans
- Immunogenicity of engineered monoclonal antibodies
- Quiz on antibody engineering
Monoclonal Antibody Therapy
- Immunotoxins
- Recombinant Immunotoxins
- Humanised and Fully Human Immunotoxins
- Bispecific Antibodies or Heteroconjugates
- Abzymes
- Quiz on Monoclonal Antibody Therapy
Covalescent Plasma Therapy for the treatment of COVID-19 disease
- Structural proteins of SARS-CoV-2
- What is Plasma Therapy or Passive Immunization?
- How is plasma therapy done?
- Limitations of Plasma Therapy
- Quiz on Plasma Therapy
Monoclonal antibody therapy for the treatment of COVID-19 disease
- Monoclonal antibodies and COVID-19
- Isolation of monoclonal antibodies from COVID-19 recovered patients
- How plasma therapy & monoclonal antibody therapy are different from vaccination?
- Quiz on monoclonal antibody therapy for COVID-19
What's next?
- What's next?
Instructors
Ms Roohi Bansal
instructor
Freelancer
Other Masters, Ph.D