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Why is HbF curve to the left of HbA curve in oxygen-dissociation graph?


Ram Mohan Nayak 10th Mar, 2019
Answer (1)
masteranshu27 10th Mar, 2019

Fetal Hemoglobin (HbF) has higher affnity towards oxygen as compared to Adult Hemoglobin (HbA) as HbF binds less strongly to BPG (Bis-phosphoglycerate) (BPG reduces oxygen affinity). Hence HbF can carry upto 30 percent more oxygen as compared to HbA. Therefore, oxygen-hemoglobin dissociation curve for HbF will appear on left side.

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