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Hello Aspirant,
No you cannot if you have additional subject as Mathematics along with Physics, Chemistry and Biology, the reason being, you are only eligible JEE-Main 2022 if you have Physics and Mathematics as compulsory subjects as per the latest eligibility criteria of JEE-Main, which you can check out from the link given below :-
https://engineering.careers360.com/articles/jee-main-eligibility-criteria
If you are preparing for JEE-Main 2022 then enlisted preparation tips would be helpful for you :-
For more detailed preparation tips for JEE-Main 2021 kindly check out the link given below :-
B.Tech/B.Arch Admissions OPEN
https://engineering.careers360.com/articles/jee-main-preparation-tips
I hope this information helps you.
Good Luck!!
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