Hello ,

Characteristics of Tight Junctions :

• These are also known as zona occludens
• Play major role in maintaining epidermal barrier permeability by regulating the paracellular flux of water soluble molecules between adjacent cells
• They help in formation of blood brain barrier.
• Major tight junction proteins are Claudins and Occludins
• Tight junctions are responsible for resorption of magnesium ion from thick ascending loop of henle
• Mutation in tight junction protein claudin leads to familial hypomagnesemia with hypercalciuria and nephrocalcinosis.