Hello.
The eligibility criteria for btech in biotechnology is as follows

Qualification: Pass in 10+2, A Level, IB, American 12th grade or equivalent with Physics, Mathematics and English as compulsory subjects along with Chemistry or Biotechnology or Biology or any technical vocational subjects as optional with a minimum of 50% marks taken together in Physics, Mathematics and any one of the optional subjects.
According to the eligibility criteria you need maths as an compulsory subject to opt for btech in biotechnology.

Goodluck