Hi ,450 marks are fine but in order to secure a seat in government medical college you need to score 520 + marks as it will increase your chances of getting seat. In a way cutoff generally is higher as compared to previous year plus cutoff varies every year depending on several factors like number of students appearing in exam, difficulty level of exam, students scoring more than you and your category.
You didn't mention your respective State to which you belong to or you have query about and your category as well. If there's anything in particular to ask  do let us know.
Hope this helps

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