Geetha, by any chance did you mean IISER? If yes, you can appear for IISER if you have studied your 12th with Mathematics as your main subject. According to the eligibility criteria mentioned in the official website: http://www.iiseradmission.in/index.php/pages/eligibility , you should have completed your 12th with Science Stream. With MPC, yes you can appear for IISER Test.