Hi Tamoghna,

Inhibition of specific enzymes by drugs are useful for medicine.Mechanism of enzyme is an important part to study. There are four types of enzyme inhibition – competitive, non- competitive, uncompetitive, and suicide. Of these, the first three types are reversible and the last one is irreversible.

Feel free to ask doubts in the Comment Section.

I hope this information helps you.

Good Luck!

Hello Student,

I guess you are talking about Inhibition of Enzymes

Different Types of Inhibition :

• Competitive - Competitor resembles substrate and binds to active site

Km value increases but Vmax remains same

E.g : Malonate inhibits succinate dehydrogenase, Sulpha drugs inhibit folic acid synthase

• Non-Competitive - Competitor binds to sites other than the active site

Km remains same but Vmax decreases

E.g - Cytochrome oxidase inhibition by cyanide ions

• Allosteric or Feedback Inhibition - Competitor binds to a site other than the active site which results in modulation of the active site.

E.g - Inhibition of Threonine Deaminase by Isoleucine, Inhibition of Phosphofructokinase by ATP, Inhibition of Hexokinase by Glucose-6-Phosphate.