A very good question.

Your first Question : What is the difference between CSE and CSE with any specialization?

Ans: CSE deals with all the aspects which are related to computer science and engineering, whereas CSE with specialization involves mostly your specialization . For example, if choose CSE with cybersecurity then the major focus will be to make you excellent in cybersecurity whereas, Normal CSE is a comprehensive course in computer applications and system. It deals with designing and developing computer software and hardware processes. Through this course, the students will be able to understand, learn and use different programming languages, digital and analog electronics, networking and telecommunications, etc.

But there is a catch, with normal CSE too, you can study that specialization technology, not only this colleges nowadays are giving options for AI, ML when a student enters in 5th semester.

Question 2: Will they have different weightage during campus placement?

Ans: Not too much but a very slight difference as of now. In some cases, you might be getting the benefit of taking Computer Science with specialization . For example, a company whose major work is based on cybersecurity then for the obvious reason they will first give priority to the guy who has done CSE with cybersecurity as a specialization. But remember that, specialization makes you confined too because there are not a large number of companies that are based on your specialization, so in this case, Normal CSE has an edge, as there are bulk of companies for them, though most of them allow to sit the specializations students, too but few of them might not allow sitting.

I hope it clears your doubt. Feel free to connect me in the comment section if still having doubts.

All the best!