Hello Aryan! Let me tell you the major difference between COMEDK & Uni- GUAGE E. 

Both COMEDK & Uni-GUAGE come under entrance exmas but, COMEDK entrance exam is written to get an admission in private Karnataka Engineering colleges. The exam is conducted all over India but the counselling happens at the respective dates at Banglore.

Whereas, Uni-GUAGE entrance exam is written to get an admission in any private college across all over India.

Both have one exam, one question paper but in the end we will be getting two different scorecards and depending on it you can apply for the colleges related to COMEDK or Uni-GUAGE.

I hope this might help you.

All the best!