Hello Mamta,

The Pancreatic juice secretion is primarily regulated by the hormones secretin and cholecystokinin , produced by the walls of the duodenum, and by the action of autonomic innervation.

The release of these hormones into the blood stream is further stimulated by the entry of the acidic chyme into the duodenum.

Hope this helps you. We wish you the best for your future endeavours!

Regards

Gastrin stimulates pancreatic cells to stimulate the flow of pancreatic enzyme. There are 3 hormones that hold the important stimuli for pancreatic secretion.

Cholecystokinin is synthesized and secreted by enteric endocrine cells. These cells are located in the duodenum. While Chyme flows into the small intestine, cholecystokinin is released into the blood. This binds to the receptors on pancreatic acinar cells, and orders them to secrete larger quantities of digestive enzymes.

Secretin is a product of endocrinocytes and they are located in the epithelium of the small intestine. When duodenum releases acid, secretin is secreted in response to the acid. Secretin stimulates the duct cells to secrete water and bicarbonate. Then immediately the acinar cells get flushed out of the pancreas via the pancreatic duct into the duodenum.

Gastrin is secreted in larger amounts by the stomach due to gastric irritation. Gastrin stimulates the acinar cells of pancreas to secrete digestive enzymes.