Yes, JoSAA accepts marksheets from two different boards , but with conditions.
You can use CBSE + NIOS , but you must have:
Passing certificate/marksheet of the first board (CBSE).
Passing certificate/marksheet of the second board (NIOS).
Both certificates must be valid and recognized .
You may need to provide a “Demand/Eligibility Certificate” from NIOS if requested.
JoSAA only requires that you meet the 12th/qualifying exam criteria ; the boards can be different.
For official details: JoSAA 2025 Eligibility (https://josaa.nic.in/webinfo/public/home.aspx)
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