Yes, you can apply for undergraduate courses at the Indian Statistical Institute (ISI) if you have completed your 12th grade with Math and English. ISI offers a Bachelor of Statistics (B.Stat) program and a Bachelor of Mathematics (B.Math) program.

To be eligible, you generally need to have studied Mathematics in your 12th grade and meet the specific eligibility criteria set by ISI. Admission is typically based on an entrance examination that tests your knowledge in Mathematics, and sometimes also in English and other subjects, depending on the course.

Make sure to check the specific eligibility requirements and deadlines for the entrance exam on the ISI official website or contact their admissions office for the most accurate and up-to-date information.