Dear student, in 2018, 421 marks was the closing cutoff in Government Medical College, Ernakulam for OBC category student under state quota in Kerala. With 453 marks in NEET UG 2019, you have a fair chance to get a seat in this college. Having said that the cutoff tends to change every year depending on factors like top Neet score, difficulty level of the examination and a lot more. 

You can check the cutoffs for other colleges using the link:

https://www.google.com/amp/s/medicine.careers360.com/articles/neet-cutoff-kerala/amp