The requirement for the JEE Main exam can vary depending on the specific AI course and the institution offering it. Some AI courses may require JEE Main scores as part of their admission criteria, especially if they have a strong focus on engineering or computer science fundamentals.

However, many AI courses, particularly at the postgraduate level, may have their own entrance exam or may not require JEE Main score at all. It's essential to check the admission requirements of the specific AI course and institutions you're interested in to determine whether JEE Main is mandatory.