Dear aspirant....!!

Yes you can do Nursing after 12th Commerce. There is no problem for the same.

A career in nursing requires different set of skills. 
Process : 
To become a nurse there are different nursing courses available. The details for them are provided below. 
1. After Class X :--- 
18 month auxiliary nurse midwife/multi-purpose health worker courses
2. General Nursing :--- 
Eligibility - 10+2 Class pass with aggregate of 40%
Training Duration – 3 & 1/2 years
Examination- Nursing Examination Board
3. B. Sc (Basic) :--- 
Eligibility- 10+2 Class Pass with 45% aggregate in PCBE
Training Duration – 4 years
Examination- University 
Nursing being the women specific job which is one of the most important parts of medical care system in itself where one is trained in how to take care of sick people after properly being equipped with the knowledge of science of health care. 

All the best!