hello Ajinkya Jondhale

it's all about perspective. you cann't compare apples and oranges because there is not any kind of common parameter. let me just explain the academic and career prospective for both of them

science : 12th- PCM/B

              graduation: popular choices include- engineering, bachelor of science or the medical feild

             career perspective: engineer, scientist or a doctor any many more

  COMMERCE          12th- commerce would a main subject along with economics and others

                              grad.: popular choices B.Com , BBA 

                          career perspective: CMO , CFO , CA and many more

hope it helps