Hello,

Actually in case of the difference between Soluble and particulate antigen,   the particulate antigens are internalized through antigen presenting cell (APC) phagocytosis with greater efficiency but no longer processing time. If the antigen is particulate then it is look for the process of agglutination of the antigen by the antibody but if it is soluble antigen then is must go for the precipitation of the antigen after the production of large insoluble antigen antibody complex.

Hope it is helpful for you.

Thank you.

Hi

As per your question Antigens in particulate form have awesome immunologic houses relative to soluble

antigens. An expertise of the mechanisms and functional outcomes of the wonderful immunologic

pathways engaged with the aid of these different styles of antigen is particularly applicable to the design

of vaccines.

It is also relevant concerning the usage of therapeutic human proteins in clinical medicinal drug that

have been proven to aggregate, and possibly as a result, elicit autoantibodies.

Differences Between Soluble and Particulate Antigens Relevant to the Immune Response

Relative to soluble antigens, antigens in particulate form are selectively internalized through antigen-

imparting cell (APC) phagocytosis, with extra efficiency (1, 2) however with longer processing time (3),

showcase quantitative and qualitative differences in the antigenic epitopes generated (4), concentrate

for extended periods in the marginal area of the spleen (5), and are provided poorly,

If at all, by way of splenic B cells (4), although efficaciously internalized by using peritoneal B1b cells (6).

Signaling responses of APC can differ markedly in response to microbe-related molecular patterns which

might be expressed in particulate as opposed to soluble form (7). Various particulates, consisting of

intact bacteria activate the inflammasome ensuing in manufacturing of IL-1β (8, 9), a cytokine which

could augment T cell-based antibody responses (10).

Phagocytosis of particulate antigens via APC also augment the calcineurin/NFAT signaling pathway

resulting in a better stage of immune stimulation (7).

Hope helpful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871672/