As far as DU is considered, you need to add those subjects in four in which you have scored maximum marks including a LANGUAGE subject like Hindi, Sanskrit, Malyalam etc.
You will get benefited if you add one subj related to your stream in which you are going to take admission like you must add computer science in best four if you have studied it in your 12th and taking admission in B.Sc computer science.
So here we conclude that you can consider Malayalam as one of the best four for sure.
Thank you and All the best.

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