The cutoff for Mumbai last year government colleges for General category last year was around 533. The cutoff in Rest of Maharashtra region, Vidarbha and Marathwada including everything was around 486 in the previous year. But the cutoff is expected to rise this year as the paper level was easy as analyzed by the experts and also keeping into consideration the increased number of candidates. So the cutoff maybe expected to be around +15. So if you stay in Mumbai and want colleges from Mumbai itself, the cutoff will be around 545s and for other parts of Maharashtra you can expect around 500. 

Best wishes. 

Hi Aspirant, cutoff marks cannot be definitive and predicted beforehand due to the number of varying reasons such as number of applicants and the difficulty of exams. However, you can check the last year cutoff to get a general idea here:

https://medicine.careers360.com/articles/neet-cutoff-maharashtra

Hope it helps, All the best!