Hello, CSE is a branch which is highly in demand. The rank cut off for getting CSE in the main campus is generally less than 2500. To get rank less than 2500, it is important that you score more than 50% marks in your entrance test which means you need to score somewhere around 500 to 550 marks to be confident of getting a seat in CSE branch in the main campus of Manipal University.

Hope its helpful for you :)