The only way to get into IISc without KVPY is through Joint Entrance Exam .

hi prasaman, the entry level to get into IISC UG, students desirous of applying to the bachelor of science (Research) Programme must take at least one of the above examinations -

• KVPY
• IIT-JEE(Main and Advanced)
• NEET

The Institute will make use of the merit lists of these competitive national level entrance exams.   

So there is no other way to get into IISc UG without giving any of the above mentioned exams