It is a five year degree program for bright and motivated science students who have passed (10+2) level. The program integrates classroom learning with research and provides ample scope for multidisciplinary interactions. The first two years of the program consist of core courses in basic sciences, the third and fourth years are dedicated to specialization in chosen science subjects and the fifth year includes a research project. The training during the program enables students to pursue a career in academia, R&D institutes, and science-based industries. For candidates seeking admission to BS-MS dual degree in Engineering Sciences stream of IISER Bhopal, Mathematics at 10+2 level is mandatory.

From this year onward a four year BS programme in Economic Sciences is also being introduced in IISER Bhopal for students having mathematics at 10+2 level.