Step 1: Write the problem

243/-333 × -296/162

Step 2: Multiply the numerators

243 × -296 = -71928

Step 3: Multiply the denominators

-333 × 162 = -53946

Step 4: Write the new fraction

-71928/-53946

Step 5: Simplify the signs

Negative divided by negative becomes positive:

71928/53946

Step 6: Reduce the fraction

Divide both top and bottom by 8982 (the greatest common divisor):

71928 ÷ 8982 = 8
53946 ÷ 8982 = 6

So: 8/6

Step 7: Simplify further

8/6 simplifies to 4/3

Final answer

243/-333 × -296/162 = 4/3