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Hello Abhishek,
Yes you can get admission into IISc Bangalore with JEE mains. For admission to B.Sc (Research), the you must have passed 10+2 from a recognized board of education.For B.Sc (Research) aspiring you must possess valid KVPY/ JEE Main/ NEET-UG scores.and you can make through into it.
I hope this helps.
All the best.
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