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you must atleast get 450+ to get Madras Medical College under the state quota while under all india you must have 500 plus since the competation is quite high medical feild

85% seats at Madras Medical College are reserved for State Quota and rest 15% for All India Quota. Apart from this, caste-based state reservation system is also followed by the institute

regards

Madras medical college is usually one of the premier medical colleges in the state and you should be able to get an excess of 550 out of 720 in order to qualified to the college availing the 85% state quota keeping in mind the probable cut offs of the last few years
for availing the college using the 15% all India quota without having to use your domicile you must try to score in excess of 620 out of 720 to be comfortably through,  there will be high level of competition also the cut offs may go but lower depending on whether the paper is tough or how your competitors have performed in the examination

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