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Yes Rakshith, you can get admission in IISc with 1650 rank in JEE Mains. the cutoff is generally AIR 250 for general category and up to 3000 for OBC NCL(PWD) category. There are many of my friends who got admission through JEE main rank.
Check the IISc college website for further information--
https://www.iisc.ac.in/
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