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Quick Facts

Medium Of Instructions	Mode Of Learning	Mode Of Delivery
English	Self Study	Video and Text Based

Course Overview

This is a massive open online course on the fundamentals of human genetics for the students of undergraduate level. This online program is focused on delivering insights on various diseases related to human genetics and the aspects of genotype and phenotype. This online certification course is provided by the Swayam portal in collaboration with the Consortium for Educational Communication (CEC). The classes are held online for a period of six weeks and the students of this elective course will gain experiential learning.

The course instructor for this program is Prof. Md. Niamat Ali from the Environmental Science department, P. G. Centre of Microbiology at Centre of Research for Development (CORD) in the University of Kashmir. The students of this course are provided with course modules and other online resources to develop a detailed understanding of the concepts.

The ‘Basic Human Genetics’ online certification program ensures students with knowledge acquisition along with the E-Certificate and credit points for this program under the Biological Sciences & Bioengineering domain.

The Highlights

Online mode
Six weeks
Elective program
Expert faculty
Credit points
E-Certificate

Programme Offerings

Course Modules
Online Classes
Books
references
assessments
Final Exam
E-certificate
Credit Points

Courses and Certificate Fees

Certificate Availability	Certificate Providing Authority
yes	Kashmir University

Eligibility Criteria

Certificate qualifying details

The students of this ‘Basic Human Genetics’ certification by Swayam will become eligible for the course certificate after completing the course with a score of 30% in the internal assessments and 70% in the final examination.

What you will learn

Knowledge of BiologyKnowledge of geneticsKnowledge of MicrobiologyKnowledge of ecosystemKnowledge of biomedical sciences

The ‘Basic Human Genetics’ certification syllabus is developed for the students to learn about the different aspects of human genetics and their applications. The students of this course will gain knowledge about the significance of genes in human biology to comprehend the evolution of genomics and human genetics that enable the understanding of genetic diseases. This helps the candidates in enhancing their knowledge of the prevention and cure of those diseases. The aim of this program is to provide an understanding of the historical views of human genetics, the human genome project, and the various tools and strategies involved in this field.

Who it is for

GeneticistBiologist

The ‘Basic Human Genetics’ online certification program is designed to enhance the knowledge of the students and graduates pursuing the field of biological sciences and bioengineering.

Admission Details

The candidates of the ‘Basic Human Genetics’ online course are required to register online through the course website.

Step 1: Go to the course page using the link,

https://onlinecourses.swayam2.ac.in/cec21_bt21/preview

Step 2: Find the ‘Sign-In/Register’ link.

Step 3: Fill in the details for registration.

Step 4: Join the course.

Application Details

The students of the ‘Basic Human Genetics’ certification course are required to apply for the course by entering the course account details on the registration form or can sign in using the Google, Facebook, or Microsoft account IDs.

The Syllabus

History of Human Genetics: Pedigree Analysis (Pedigree symbols and construction of pedigrees, inheritance pattern and risk assessment, Presentation of molecular genetic data in pedigrees)
Patterns of Inheritance for Monogenic Traits: Autosomal inheritance-dominant, recessive, sex-linked inheritance, sex-limited, and sex- influenced traits, and mitochondrial inheritance
Deviations from the basic pedigree patterns, nonpenetrance, variable expressivity, pleiotropy, late-onset, dominance problems, anticipation, genetic heterogeneity, and uniparental disomy. X-inactivation and dosage compensation
Mosaicism and chimerism, consanguinity and its effects, epigenetic modifications, and imprinting

Human Genome Project: History, organization, and goals of the human genome project.
Tools (Vectors- BAC, PAC, YAC, and sequencing techniques) and approaches (Hierarchical and shotgun sequencing), outcomes ethical issues, and applications in human diseases.
Organization of the Human Genome: General features: Gene density, CpG islands, RNA-encoding genes
Gene clusters, diversity in size and organization of genes, types of repetitive DNA, pseudogenes, gene families
Endoreplication and amplification, genetic markers, and their applications

Human Cytogenetics Technique: Fluorescence in situ hybridization (FISH)
Human karyotype:
- Banding pattern and nomenclature (G and Q banding)
- Common syndromes due to numerical chromosome changes
- Common syndromes due to structural alterations(translocations, duplications, deletions, microdeletion, fragile sites, common chromosome abnormalities in cancer
Techniques for Genomics: DNA sequencing (Maxam-Gilbert and Sanger Method, introduction to NGS), DNA fingerprinting

Polymorphism screening (genotyping of SNPs )
Microsatellite markers, expression, and proteome analysis.
Population Genetics: Genotypic and allelic frequencies, linkage disequilibrium, haplotype construction (two loci using SNPs and/or microsatellites).
Mapping Strategies: Physical maps (different types- restriction, cytogenetic maps, use of FISH in physical mapping, radiation hybrids and clone libraries in STS mapping) and genetic maps

Identification of Genetic Basis of Disease
Principles and strategies, positional and candidate gene approaches, positional- cloning approach (examples- HD, CFTR), the concept of twin and adoption studies
Prenatal Diagnosis: Brief introduction, methods of prenatal diagnosis
Clinical Genetics: Inborn errors of metabolism and their genetic basis (example- phenylketonuria), genetic disorders of hemopoietic systems (examples- sickle cell anemia and thalassemia)
Genetic basis of color blindness

Biosafety of human genetics:
- Biosafety for Human Health and Environment.
- Biosafety issues for using cloned genes in Medicine, Agriculture, Industry, and Ecoprotection.
- Gene Pollution, Biological Invasion, Risk and Safety Assessment from Genetically Engineered Organisms
- Special Procedures for r-DNA based products
- Biological Warfare, Biological Containment (BC) and Physical Containment (PC)
- CDC Biosafety levels, Biosafety in Clinical Laboratories and Biohazard Management.
Bioethics of human genetics:
- Ethical Issues of the Human Genome Project
- Code of Ethics in Medical/clinical laboratories
- Ethical Issues of Xenotransplantation.
- Ethics involved in Embryonic and Adult Stem Cell Research
- Ethics in Assisted Reproductive
- Technologies: animal and human cloning and Invitro fertilization, the element of Informed Consent