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    Quick Facts

    Medium Of InstructionsMode Of LearningMode Of Delivery
    EnglishSelf StudyVideo and Text Based

    Courses and Certificate Fees

    Fees InformationsCertificate AvailabilityCertificate Providing Authority
    INR 1000yesIIT Hyderabad

    The Syllabus

    Introductory Concepts
    • Historical perspectives; Biocompatibility; Bioactivity; Biodegradation; Biomimicry; Biomaterial classes; Protheses; Implants; Medical devices; Design-application paradigm; Clinical case studies

    Structure-Property Relationships
    • -mer/Monomer/Oligomer/Polymer; Molecular structure: backbone, end-group, side-group, co-polymer; Configuration: stereoisomers, tacticity; Molar mass; Degree of polymerization; Polydispersity

    Structure-Property Relationships
    • Chain conformation; Size: end-to-end distance, persistence length, Rg, Rh; Architecture: linear, branched, cross-linked, brush, dendrimer; Thermoplastic; Thermoset; Elastomer; Polymer synthesis

    Temperature and Solvent Effects
    • Crystalline and amorphous states; Hierarchy; Folded chain model; Phase transitions; Crystallization kinetics; Melting; Glass transition temperature; Flory-Fox & Fox equations; Microstructure & modulus

    Temperature and Solvent Effects
    • Dissolution; Solubility parameter; Solvent quality; Excluded volume; Entanglement; Viscosity; Mark-Houwink equation; Solution thermodynamics; Ideal solutions; Lattice model; Flory-Huggins theory

    Biomedical Polymers
    • Synthetic polymers; Design of sutures, hip prosthesis, soft contact lenses, dental resins, vascular grafts, bone cement; Structure-property-function-application: polyurethanes, silicones, (e)PTFE, PMMA, PEG, polyanhydrides & polyesters (PLA, PGA, PLGA, PCL); Drug release case study

    Biomedical Polymers
    • Natural polymers; Proteins; Polysaccharides; Structure-property-function-application: collagen, silk fibroin, elastin, cellulose, HPMC, chitosan, alginate, aggrecan, heparin & hyaluronic acid; Hydrogels: types, swelling, crosslink density, mesh size, Flory-Rehner theory, Merrill-Peppas equation  

    Bulk Behavior and Responses
    • Tensile testing: temperature, solvent, strain rate & microstructural effects; Stress-strain curves; Brittle-ductile transition; Elastomers; Tensile properties; Ageing; Other testing modes; Failure mechanisms

    Bulk Behavior and Responses
    • Viscoelasticity; Hooke’s & Newton’s laws; Creep; Stress relaxation; Deborah number; Hysteresis; Viscoelasticity in collagen, elastin, ligaments & tendons; Tendon testing; Linear viscoelastic models; Bulk degradation: routes & mechanisms  

    Biomaterial Processing
    • Scaffold preparation techniques; Sterilization methods; Polymer electrospinning: physical insights, nanofiber preparation, demonstration, controlled release; Additive manufacturing & 3D printing

    Surfaces and Interactions
    • Biomaterial surfaces: properties, modification & ECM interactions; Protein adsorption: thermodynamic, kinetic and steric effects; Monolayer theory; Competitive adsorption; Vroman effect; Blood-polymer interactions; Hemocompatibility; Anti-thrombotic surfaces

    Biomaterial Performance
    • Biomaterial implantation; Inflammation; Foreign body response; Fibrous encapsulation; Immune response; Medical devices; Device testing; Biocompatibility; Translation; Clinical case studies; Device failure; Device regulation; Regulatory agencies

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