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    Quick Facts

    Medium Of InstructionsMode Of LearningMode Of Delivery
    EnglishSelf StudyVideo and Text Based

    Courses and Certificate Fees

    Fees InformationsCertificate AvailabilityCertificate Providing Authority
    INR 1000yesIISc Bangalore

    The Syllabus

    • Brief review of the fundamentals of molecular biology and genetics. 
    • Examples of widely used software, algorithms, databases.

    • Z-algorithm, suffix arrays, suffix array construction

    • Suffix trees, suffix tree construction, applications of suffix trees

    • Burrows-Wheeler Transformation, BWT index, Generalised rank operations, succinct suffix arrays
    • Classic dynamic programming ideas for pairwise sequence alignment. 
    • Edit distance, global alignment

    • Local alignment, Incorporating gaps in alignments
    • Statistical measures of alignment significance.

    • Mathematical ideas underlying heuristic sequence aligners.
    • Maximal unique matches, co-linear chaining

    • Incorporating gaps into the chaining algorithm
    • Applications of sequence alignment for mutation finding and disease diagnosis.
    • Shortest common superstring formulation for genome reconstruction

    • Greedy approach to genome reconstruction
    • de Bruijn Graphs, Overlap graphs

    • Multiple sequence alignment – formulations, optimal and approximation algorithms
    • Classical and contemporary algorithms for inferring evolutionary trees.

    • Gene finding. Hidden Markov models
    • Large language models for biological sequences

    • Overview of pangenome representations
    • Aligning sequences to a pangenome

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