Structural Biology
Learn about the 3D architecture of protein molecules used in Next Generation Sequencing (NGS) by enrolling in the Structural Biology online course by Swayam.
Online
12 Weeks
Free Quick Facts
| Medium Of Instructions | Mode Of Learning | Mode Of Delivery |
|---|---|---|
| English | Self Study | Video and Text Based |
Course Overview
The Structural Biology certification syllabus has been purposefully designed for Biological Sciences, Biosciences, and Bioengineering students. Over 12 weeks, it will educate you on structural units forming biological macromolecules. Their hierarchies, pros & cons, and visualizing 3D structure files will also be discussed.
Approved by AICTE, the Structural Biology course by Swayam will also introduce you to molecular dynamics using various case studies. So, you will know how to apply the acquired knowledge effectively.
The Structural Biology certification course links biological events to deduce how biological macromolecules are folded, generated, and become functional. As such, the course will equip you to take on further advanced studies in drug designing and macromolecule-based engineering.
Swayam offers the Structural Biology program at an introductory level. Replete with case studies, books, and references, the course ensures you have a holistic learning experience. And if you want to certify your learnings, you can also take the certification exam and obtain the course certificate.
The Highlights
- Introductory course
- A course by IIT Roorkee
- Online learning
- E-certificate
- Free enrolment
- UG/PG level course
- A course in Biological Science and Bioengineering
- Case studies
- FDP course
- Approved by AICTE
Programme Offerings
- online learning
- Free registration
- UG/PG level course
- course certificate
- introductory course
- Weekly lectures.
Courses and Certificate Fees
| Fees Informations | Certificate Availability | Certificate Providing Authority |
|---|---|---|
| INR 1000 | yes | IIT Roorkee |
- You don't need to pay to enroll in the Structural Biology course by Swayam.
- The course certificate costs Rs 1,000.
The Structural Biology fee structure -
Course Option | Fee |
Structural Biology (Program content access only) | FREE |
Structural Biology (Certificate + course content access) | Rs. 1,000 |
Eligibility Criteria
While there are no specific prerequisites for registering in the Structural Biology program, having a basic knowledge of Biology will help in comfortable learning.
Moreover, Swayam only offers the Structural Biology certificate to candidates who meet the two qualification conditions. Your average assignment score should be >= 10/25, and your exam score needs to be >= 30/75.
25% of your average assignment score, calculated using 8 of your assignments with the best scores, and 75% of your exam score are added to determine the final score. Your final score must be >= 40/100 to qualify for the course certificate.
What you will learn
Structural Biology online course will help you master the following topics:
- Protein architecture
- Structural Biology techniques
- Nuclear Magnetic Resonance (NMR)
- 3D Structure visualisation
- Molecular dynamics
- Macromolecular Crystallography
- Protein folding
- Enzymes
Who it is for
Students and research scientists studying/working in disciplines like Pharmaceuticals, Bioinformatics, Biotechnology, Chemistry, and related programs can benefit from taking the Structural Biology course by Swayam. Veterinarians and clinicians who want to undertake research can also join this introductory course.
Admission Details
Step 1: Use the web link https://onlinecourses.nptel.ac.in/noc25_bt41/preview to access the Structural Biology online course by Swayam.
Step 2: Now, find the 'Register/Sign-up' button on the webpage and tap it. Swayam's online registration page will open.
Step 3: You can log in via social accounts (Swayam/Facebook/Microsoft/Google) or start a new learning account by providing the details as asked. Once registered, fill the online form.
Step 4: Swayam will notify you by sending a mail to your registered email ID on successful enrolment.
Application Details
The structural Biology program has a dedicated application form that you need to fill out. You can access it by signing up on Swayam. To do so, you must provide a username, password, and email address to complete the form and press 'submit'. You will receive an email on successful registration.
The Syllabus
Introduction
- What is post NGS era, why structural biology become so important, How to read biological macromolecules, Sequence to structure to function relationship, Protein as our target study molecule
Protein Architecture
- amino acids structure and function, Primary, secondary, tertiary and quaternary structure of protein; Motifs and domains of protein structures; Conformational analysis, Protein folding
Bonds and energies in macromolecules
- Covalent, Ionic, coordinate, hydrophobic and Vander walls interactions
Enzymes
- introduction to enzymes, how enzyme develop magic pockets, enzyme-ligand interaction, Structure-function relationship,
Structural Biology Techniques
- Basics of macromolecular crystallography, Nuclear Magnetic Resonance (NMR) and Cryo-Electron microscopy, advantages and disadvantages of all the processes: comparative discussion
Macromolecular Crystallography: Crystallization and Data Collection
- Crystallization, method of protein crystallization, thermodynamics and kinetics of protein crystallization, structural genomics project
Macromolecular Crystallography: Data Analysis
- X-ray diffraction and Bragg equation, scattering factor, Structure factor expression, Phase problem and methods for phase determination, structure determination of macromolecules by crystallography technique
Reading and Understanding 3D structure files
- Introduction to PDB data, RCSB, reading PDB files, related calculations
3D structure Visualization
- Visualization of macromolecules using Pymol and Coot
Introduction to Molecular Dynamics Simulation
- Need of simulation in studying biology, Building realistic atomistic model, Size and Times scale of macromolecular movements, Atomic Interactions: bonded and non-bonded, General form of all atom force field equations, Steps in molecular dynamics, Topology and parameter files, Periodic boundary conditions, Solvation and solvation methods, Simulation programs
Applicative measures01
- Case studies: Structure based drug designing
Applicative measures02
- Case studies: Protein Engineering
Evaluation process
You must appear for the optional certification exam conducted by Swayam to receive the Structural Biology certificate. The exam will take place in person at one of Swayam's designated exam centers, and it will be proctored.
Exams are held in two slots, namely morning session (9 AM – 12 noon) and afternoon session (2 PM – 5 PM). You can register once they announce the exam and open the portal.
Instructors
IIT Roorkee Frequently Asked Questions (FAQ's)
Yes. Having a basic knowledge of Biology may have helped, but since the Structural Biology program is offered at the introductory level, you can still join it.
Other than the weekly lectures, there will be assignments, case studies, and one optional proctored exam towards the course end.
Yes. It is an AICTE-approved FDP for Faculty Development Program.
Yes. The entire curriculum will be instructed in English.
Yes. The Structural Biology certificate will also have your name and photograph along with your final score.