In COMEDK colleges what is the difference between CSE and ISE and INS courses.

Hello aspirant, definitely there is a difference between all the 3 courses. Each of them deals with a particular concept in detail. CSE and INS are preferred more. You are lucky enough to get CSE. It's the one which has most demand. Getting placed is easy with CSE background. That's why most of the candidates opt for it. You can opt any one of these based on your interest and the college you get for your rank.
Go through below links for more details.

https://www.careers360.com/list-of-engineering-courses-in-india

https://www.careers360.com/all-courses

All the Best.